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O. S. Enoghama ¹, A. A. Uwakwe ¹, F. C. Onwuka ¹

Affiliations
1 Department of Biochemistry, University of Port Harcourt, NG

Abstract

Griseofulvin, an antifungal agent was investigated invivo for its possible effects on some haematological and histological parameters of wistar albino rats (Rattus rattus). Different concentrations (0.1, 0.3. 0.7, and 1.0 mg/ml) of griseofulvin were administered to wistar albino rats (Rattus rattus). Packed cell volume (PCV), blood haemoglobin (Hb), white blood cell (WBC) counts were monitored periodically (weekly) for four weeks. The results showed that there were significant reduction P=<0.05 in both PCV and blood haemoglobin values. The highest decrease in PCV and Hb values was observed in fourth week (25.0±1.4) as compared to the control (41.0±2.0) for PCV and Hb (7.76±1.3) as compared to the control (13.60±1.8). There were significant increase P(<0.05) in the WBC count, with the highest increase in the first week(12.70±2.4) as compared to the control of (8.50±0.2).Histological examinations of the rat's liver tissue was also carried out following administration of griseofulvin. It was observed that griseofulvin did not cause any serious damage to the rat's liver tissues.

Keywords

Griseofulvin, PVC, Hb, WBC

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